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These studies suggest that GLP-1RA may inhibit TCR signaling in a GLP-1R-dependent manner, thereby reducing systemic and intestinal inflammation induced by CD8 + T cells and other factors (anti-CD3 induction) ( In summary, GLP-1RAs have the potential to inhibit neuroinflammation and promote nerve regeneration through the "Tregs-microglia-neuron/NPCs" axis: (1) GLP-1RAs directly and indirectly inhibit the activation of microglia, promote their M2 polarization, and secrete cytokines such as IL-4, IL-10, TGF - β, IL-2 to exert anti-inflammatory effects ( 6 Perspective Although multiple cytokines (IL-4, IL-10, etc.) together inhibited neuroinflammation in neurological disorders, their functions were significantly different
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